Endocrine Abstracts

Hashimoto’s thyroiditis (HT) is a chronic disease that needs a daily substitution by thyroid hormones. The purpose of this study was to assess the level of therapeutic adherence to the hormonal treatment in HT patients and its impact on the thyroid function control.MethodsIt is a cross sectional study including 43 patients treated for hypothyroid Hashimoto’s thyroiditis by levothyroxine (LT4). The patient adherence to tre...

BackgroundPatients with Subclinical Cushing’s Syndrome (SCS) share many similarities with those of metabolic syndrome. Several studies have shown variable prevalence of SCS in patients with diabetes and obesity of up to 9% suggesting that it may be more common in these patients. Our study aims to explore the prevalence of SCS in Malaysians with metabolic syndrome and examine any possible predicting factors.Methods<p class=...

Introduction: The reason for weight gain is multifactorial. Effective intervention can only be incorporated if the underlying cause is evaluated correctly. Here we present a lady with Addison’s disease who gain significant weight and was helped to lose weight using a novel approach.Case-Report: 42 year-old lady was referred to our weight-management service as she was unsuccessful in losing weight. Detailed evaluation in the obesity clinic revealed t...

Background: Hashimoto’s thyroiditis (HT), the most prevalent autoimmune disorder of the thyroid (AITD) is characterized by the presence of circulating autoantibodies, induced by a not fully understood dysregulation of the immune system. MicroRNAs (miRNAs) are small noncoding RNAs, which can play a pivotal role in immune functions and the development of autoimmunity. The aim of the present investigation was to evaluate whether a panel of nine selected miRNAs differs in ser...

Introduction: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis. In recent years, two prognostic scoring systems incorporating relevant clinicopathological features of ACC (ENSAT stage, grade, resection status, age at diagnosis, tumour symptoms) have been proposed: the GRAS and S-GRAS scoring systems. The prognostic value of these systems has been demonstrated in large, multicentre studies.Aim: To su mmarize the clinicopathological f...

The pancreas originates from the definitive endoderm-derived gut epithelium. Much has been learnt about the specification of the gut endoderm into pancreatic progenitors and their progenies, the endocrine (islets of Langerhans) and exocrine cells, by various transcription factors. However, less is known about the extracellular cues that regulate the expression of such transcription factors. Human ES cells have emerged as a potential tool for studying human pancreas development...

Introduction: Cushing’s syndrome can impair the gonadotrophic axis in women of child bearing age if left untreated. Furthermore undergoing endoscopic transphenoidal surgery can render patients hypogonadal, thereby reducing the chances of spontaneous conception. In such cases, pregnancy is usually achieved by assisted contraceptive techniques. We present a case of spontaneous pregnancy following transphenoidal surgery and bilateral adrenalectomy.Case...

Introduction: The use of Inferior Petrosal Sinus Sampling (IPSS) to differentiate between central and ectopic ACTH dependent Cushing’s, although requires expertise, is widely available. The value of adding prolactin measurement to that of ACTH to improve IPSS diagnostic accuracy remains controversial. We evaluated the impact of adding prolactin measurement to IPSS procedures at a large academic center.Methods: Leftover samples from patients who were...

Background: Autoimmune Addison’s disease (AAD) is a rare endocrinopathy arising from a complex interplay between multiple genetic susceptibility polymorphisms and environmental factors. Several variants in immune pathways have been identified through hypothesis-driven candidate gene analysis, though these associations can prove difficult to replicate. The first genome wide association study (GWAS) with patients from Scandinavian Addison’s registries identified associ...

Background: Cushing’s syndrome (CS) is estimated to have a 10-fold increased risk of venous thromboembolism (VTE) compared with the normal population with VTE accounting for 3.6-11% deaths in CS patients. There are no specific guidelines for VTE prophylaxis in CS other than that it should be considered given the increasingly recognised risk.Methods: Via the Society for Endocrinology, we surveyed current VTE anticoagulation practice across UK Endocri...